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Rabbit Anti-GPR30/PE-Cy5 Conjugated antibody (bs-1380R-PE-Cy5)
訂購熱線:400-901-9800
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說 明 書: 100ul  
100ul/2980.00元
大包裝/詢價
產(chǎn)品編號 bs-1380R-PE-Cy5
英文名稱1 Rabbit Anti-GPR30/PE-Cy5 Conjugated antibody
中文名稱 PE-Cy5標記的G蛋白偶聯(lián)受體30抗體
別    名 G Protein Coupled Receptor 30; G-protein coupled receptor 30; G-protein coupled estrogen receptor 1; Membrane estrogen receptor; mER; Chemokine receptor-like 2; IL8-related receptor DRY12; Flow-induced endothelial G-protein coupled receptor 1; FEG-1; Lymphocyte-derived G-protein coupled receptor; LYGPR; GPCR-BR; CEPR; CMKRL2; DRY12; GPER.  
規(guī)格價格 100ul/2980元 購買        大包裝/詢價
說 明 書 100ul  
研究領(lǐng)域 細胞生物  神經(jīng)生物學(xué)  信號轉(zhuǎn)導(dǎo)  細胞膜受體  G蛋白偶聯(lián)受體  表觀遺傳學(xué)  G蛋白信號  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應(yīng) Human, Mouse,  (predicted: Rat, Chicken, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用 Flow-Cyt=1:50-200 IF=1:50-200 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 42kDa
性    狀 Lyophilized or Liquid
濃    度 1mg/ml
免 疫 原 KLH conjugated synthetic peptide derived from human GPR30
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產(chǎn)品介紹 background:
G protein-coupled receptors (GPRs, or GPCRs) contain 7 hydrophobic transmembrane domains embedded in hydrophilic intra- and extracellular loops and transduce a variety of hormone, endogenous peptide, and neurotransmitter signals into intracellular effects via G proteins. GRP30 is a member of this family and is an orphan receptor. GPR30 expression has been reported in brain, breast carcinoma, blood, bone marrow, CNS, heart, liver, lung, lymph node, placenta, and spleen. In brain, GPR30 is expressed as a 2.8 kb transcript in basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen. However, unlike other known G protein-coupled receptors, GPR30 localizes to the endoplasmic reticulum, where it specifically binds estrogen and estrogen derivatives.

Function:
Receptor for estrogen.

Subcellular Location:
Cell membrane. Endoplasmic reticulum membrane. Golgi apparatus membrane. Protein has been detected in the cell membrane, endoplasmic reticulum and Golgi apparatus. It is currently unclear whether this is a cell surface or intracellular receptor.

Tissue Specificity:
Ubiquitously expressed, but is most abundant in placenta. In brain regions, expressed as a 2.8 kb transcript in basal forebrain, frontal cortex, thalamus, hippocampus, caudate and putamen.

Similarity:
Belongs to the G-protein coupled receptor 1 family.

Database links:

Entrez Gene: 2852 Human

Entrez Gene: 76854 Mouse

Entrez Gene: 171104 Rat

Omim: 601805 Human

SwissProt: Q99527 Human

SwissProt: Q8BMP4 Mouse

SwissProt: O08878 Rat

Unigene: 20961 Human

Unigene: 389706 Mouse

Unigene: 9806 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.


GPR30是一種膜性雌激素蛋白受體又稱非基因型雌激素膜性受體GPR30。GPR30受體廣泛表達于海馬、下丘腦、子宮、卵巢、乳腺、骨和心血管等全身多個系統(tǒng)、器官和組織,在細胞內(nèi)主要定位于細胞膜、內(nèi)質(zhì)網(wǎng)、線粒體和高爾基體。 GPER與雌激素結(jié)合, ERK、PI3K/AKT)、 cAMP等第二信使途徑發(fā)揮快速非基因效應(yīng),在神經(jīng)系統(tǒng)、生殖系統(tǒng)、運動系統(tǒng)和心血管系統(tǒng)中發(fā)揮重要的生理作用。
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