| 產(chǎn)品編號 | bs-49194P |
| 英文名稱 | Recombinant Chinese cobra Cytotoxin 1 protein, His |
| 中文名稱 | 重組眼鏡蛇蛇毒蛋白 |
| 別 名 | 3SA1_NAJAT; Cytotoxin 1 · Naja atra (Chinese cobra); Cytotoxin1; Recombinant Chinese cobra Cytotoxin 1 protein, His |
| 理論分子量 | 22.2kDa |
| 檢測分子量 | 27 |
| 性 狀 | Lyophilized or Liquid |
| 濃 度 | ＞0.5 mg/ml |
| 物 種 | Cobra |
| 序 列 | 22-81/81 |
| 純 度 | >95% as determined by SDS-PAGE |
| 純化方法 | AC |
| 內(nèi)毒素 | Not analyzed |
| 表達(dá)系統(tǒng) | E.coli |
| 活性 | Not tested |
| 標(biāo)簽 | His |
| 緩 沖 液 | 20mM Tris-HCl (pH8.0) with 0.25mM NaCl. |
| 保存條件 | Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles. |
| 注意事項 | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| 產(chǎn)品介紹 |
Basic protein that binds to cell membrane and depolarizes cardiomyocytes. It also shows lytic activities on many other cells, including red blood cells. Interaction with sulfatides in the cell membrane induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation (By similarity).
It binds to the integrin alpha-V/beta-3 (ITGAV/ITGB3) with a moderate affinity and inhibits protein kinases C (PubMed:8448165).
It also binds with high affinity to heparin (PubMed:17685633). |
| 產(chǎn)品圖片 |
The purity of the protein is greater than 51% as determined by reducing SDS-PAGE.
The purity of the protein is greater than 90% as determined by reducing SDS-PAGE.
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