| 產(chǎn)品編號(hào) | IHC0127H |
| 英文名稱 | Human CD45 Ready-To-Use IHC Kit |
| 中文名稱 | 人白細(xì)胞共同抗原CD45即用型免疫組化試劑盒 |
| 別 名 | B220; CD45; CD45R; GP180; L-CA; LCA; LY5; PTPRC; T200; CD 45; cd45 antigen; ec3.1.3.48; GP 180; L CA; Leukocyte common antigen |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
CD45 (LCA, leukocyte common antigen) is a receptor-type protein tyrosine phosphatase (PTP) ubiquitously expressed in all nucleated hematopoietic cells, comprising approximately 10% of all surface proteins in lymphocytes. CD45 is absent on non-hematopoietic cell lines, normal and malignant, non-hematopoietic tissues. CD45 glycoprotein is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases. CD45 protein exists as multiple isoforms as a result of alternative splicing, differ in their extracellular domains but share identical transmembrane and cytoplasmic domains. CD45RA is an isoform of the CD45 complex and has restricted expression between different subtypes of lymphoid cells. CD45 isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45 has been shown to be an essential regulator of T- and B-cell antigen receptor signaling and suppresses JAK kinases to regulate cytokine receptor signaling. CD45 is also important in promoting cell survival by modulating integrin-mediated signal transduction pathway, DNA fragmentation during apoptosis and inhibition or upregulation of various immunological functions. |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded human small intestine tissue slide using IHC0127H (Human CD45 IHC Kit).
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Immunohistochemical analysis of paraffin embedded human colon cancer tissue slide using IHC0127H (Human CD45 IHC Kit).
Immunohistochemical analysis of paraffin embedded human tonsil tissue slide using IHC0127H (Human CD45 IHC Kit).
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