| 產(chǎn)品編號 | IHC0278H |
| 英文名稱 | Human IRF3 Ready-To-Use IHC Kit |
| 中文名稱 | 人干擾素調(diào)節(jié)因子3即用型免疫組化試劑盒 |
| 別 名 | C920001K05Rik; IIAE7; IRF-3; IRF3; Interferon regulatory factor 3; IRF 3 |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
IFR3 (interferon regulatory factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses. It plays a critical role in the innate immune response against DNA and RNA viruses. IFR3 regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. It acts as a more potent activator of the IFN-beta gene than the IFN-alpha gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. IFR3 is found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA, or toll-like receptor signaling. It is phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Mutations in the gene can result in encephalopathy, acute, infection-induced, herpes-specific 7. |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded human pancreas tissue slide using IHC0278H (Human IRF3 IHC Kit).
Immunohistochemical analysis of paraffin embedded human gastric cancer tissue slide using IHC0278H (Human IRF3 IHC Kit).
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Immunohistochemical analysis of paraffin embedded human colon cancer tissue slide using IHC0278H (Human IRF3 IHC Kit).
Immunohistochemical analysis of paraffin embedded human tonsil tissue slide using IHC0278H (Human IRF3 IHC Kit).
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