| 產(chǎn)品編號(hào) | IHC0277H |
| 英文名稱 | Human Arginase-1 Ready-To-Use IHC Kit |
| 中文名稱 | 人精氨酸酶1即用型免疫組化試劑盒 |
| 別 名 | AI; AI256583; Arg-1; ARG1; PGIF; liver Arginase; ARG 1; ARGI1_HUMAN; Arginase1; Arginase liver; Arginase type I; Arginase I; ArginaseI; Arginase-1; Arginase1; Liver type arginase; Liver-type arginase; Type I arginase |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle. The resulting polyamines are important for cell proliferation and removal of toxins that arise from protein degradation. By degrading arginine, Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production. In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells. In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported. In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a). Arginase-1 may be expressed in the myeloid cells infiltrating tumors, and is typically found in the majority of hepatocellular carcinomas. Defects in Arginase 1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia. |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded human hepatocellular carcinoma tissue slide using IHC0277H (Human Arginase-1 IHC Kit).
Immunohistochemical analysis of paraffin embedded human lung cancer tissue slide using IHC0277H (Human Arginase-1 IHC Kit).
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