| 產(chǎn)品編號(hào) | IHC0257H |
| 英文名稱 | Human Podoplanin Ready-To-Use IHC Kit |
| 中文名稱 | 人平足蛋白即用型免疫組化試劑盒 |
| 別 名 | E11; Gp38; OTS-8; Ots8; Pdpn; RANDAM-2; RTI40; T1-alpha; T1a; T1alpha; PDPN_HUMAN; DPN; GP36; Aggrus; Glycoprotein 36 (Gp36); PA2.26 antigen; T1A; 29kDa cytosolic podoplanin intracellular domain; PICD; PSEC0003; PSEC0025 |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
Podoplanin (PDPN, T1A, gp38, Aggrus) is a mucin type-1 glycoprotein with a 40-43 kDa molecular weight. Podoplanin is expressed in many tumors and normal cells, especially lymphatic epithelial cells and follicular DCs. Podoplanin localizes in stromal cells of peripheral lymphoid tissue and thymic epithelial cells. As a regulator of the lymphatic endothelium, podoplanin probably plays a role in maintaining the unique shape of podocytes. Podoplanin appears to serve as a ligand for CLEC-2 and expression is positively correlated with tumors expressing greater invasive and metastatic potential. Podoplanin is directly involved in cell migration, aids metastases formation and tumor cell invasion of tissue. Further, it has also been determined that podoplanin expression is induced through Src activation of Cas and, recently, there are indications of podoplanin presence on Th17 cells. Initial studies below indicate the presence of podoplanin on a small but distinct population of CD4+ cells from human PBMC. Dysfunction of the podoplanin protein has been linked to diseases such as lymphangioma and subglottis neoplasm. Podoplanin has also been proposed as a marker for lung injury due to the physiological function of the protein. |
| 產(chǎn)品圖片 |
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Immunohistochemical analysis of paraffin embedded human colon cancer tissue slide using IHC0257H (Human Podoplanin IHC Kit).
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Immunohistochemical analysis of paraffin embedded human tonsil tissue slide using IHC0257H (Human Podoplanin IHC Kit).
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