| 產(chǎn)品編號 | IHC0247H |
| 英文名稱 | Human CRTC1 Ready-To-Use IHC Kit |
| 中文名稱 | 人環(huán)腺苷酸應(yīng)答元件結(jié)合蛋白轉(zhuǎn)錄共激活因子TORC1即用型免疫組化試劑盒 |
| 別 名 | CRTC1; KIAA0616; MECT1; TORC-1; TORC1; WAMTP1; BC028050.1; FLJ14027 |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PGC1alpha and inducer of mitochondrial biogenesis in muscle cells. In the hippocampus, involved in late-phase long-term potentiation (L-LTP) maintenance at the Schaffer collateral-CA1 synapses. May be required for dendritic growth of developing cortical neurons. In concert with SIK1, regulates the light-induced entrainment of the circadian clock. In response to light stimulus, coactivates the CREB-mediated transcription of PER1 which plays an important role in the photic entrainment of the circadian clock. |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded human cerebellum tissue slide using IHC0247H (Human CRTC1 IHC Kit).
Immunohistochemical analysis of paraffin embedded human ovarian cancer tissue slide using IHC0247H (Human CRTC1 IHC Kit).
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